Ilan Hammel (TAU)

will speak on

The quantal basis of secretory granule formation.

Abstract:

The classical model of secretory granule formation holds that (after transportation to the Golgi zone and some modifications), proteins are packaged for secretion by a process of concentration, forming mature secretory granules. To be more specific, qualitative electron microscopic observations have suggested that in certain cell types, "immature granules" are formed in the Golgi zone by the fusion of multiple "progranules" (whose volume can be approximately 1-2 orders of magnitude smaller than that of mature secretory granules). After undergoing further "condensation", immature granules acquire their mature appearance - the secretory granules - that reside in the cytoplasm until they are secreted to the extracellular milieu. In the current presentation I shall review our models for granule growth as a result of granule-granule fusion.

To suggest a talk (yours, or someone elses), contact Jon. Aaronson:

Back to: Jon Aaronson's homepage.

Last update on 20/10/02.