Wednesday
15-18, Schreiber bldg., room 309.
We shall give an introductory overview of key topics in Structural Bioinformatics. After a short introduction into Structural Molecular Biology and Bioinformatics, which will be given by the seminar instructor, each student will give a lecture on one of the topics outlined below. By clicking on the topic name you will get the articles, which should provide the theoretical basis for your lecture. You are welcome to supplement these articles by material from the recommended books, other scientific articles and WWW resources. A short informal guide for preparation of a bioinformatics lecture geared toward Computer Science students can be found here.
Biological sequence alignment; the dynamic programming methodology.
Hidden Markov Models and their applications to Bioinformatics.
Protein Structure Alignment; the Geometric Hashing Technique.
The course is targeted for M.Sc. and 3rd year B.Sc. students of the Computer Science School. Students of other academic units may participate if they have enough mathematical and computational maturity. No prior knowledge in Molecular Biology is assumed.
Formal Prerequisites: "Efficiency of Computation" course. Students who do not have the formal prerequisites and want to register should approach Prof. Haim Wolfson via e-mail wolfson@post.tau.ac.il.
Each seminar participant will give a lecture on one of the topics. The lectures will be scheduled for 2 hours . 15 min. of each lecture will be allocated for questions and discussion. The lecture will be followed by slides prepared with Microsoft PowerPoint, SliTex or any other equivalent software. The lecture (PowerPoint/SliTex) file will be submitted to Prof. Wolfson no later then one day after the presentation.
The grade of the seminar will be based on the lecture presentation (80%) and class participation (20%). Each student must attend at least 75% of the lectures.
Recommended Books that you can find
in the Exact Sciences and Engineering or Life Sciences and Medicine
Libraries:
A. M. Lesk, "Introduction to Protein Architecture" – biological background on protein structure.
Branden and Tooze, "Introduction to Protein Structure" – biological background on protein structure.
D. Gusfield, "Algorithms on Strings, Trees and Sequences" – everything you want to know about string/sequence matching and were afraid to ask your instructor .
Setubal and Meidanis, "Introduction to Computational Biology" – a reader friendly introduction to “classical bioinformatics”.
Bourne and Weissig, "Structural Bioinformatics" – a collection of book chapters on major topics in Structural Bioinformatics.
Recommended Web Sites: