FDR in Applications

 

A discussion of applied statistical work using FDR, organized by scientific area. [Citation numbers refer to the list below, which can be found by clicking here]

 

Medicine (general)

 

Reviews: Curran-Everett [41] mostly pairwise in Physiology; Ottenbacher [15] talks about FDR control in Epidimiology, not being aware of FDR controlling procedures.

 

Methodology: Brown &Russell [10] operating characteristics; Witte et al [35] sample size calculations; Stine & Heyse [54] estimates of overlap.

 

Applications: comparison of powder inhalers [1,2]; Pharmacological comparisons [19]; Public health policy [37, 22]; Shuttle/Mir space missions (Americans vs Russians) [44,45]; Quality of life comparisons [52].

 

Psychiatry and Neurology

 

Methodology: Ellis et al [43] developes the analysis of neurochemical maps;

 

Applications: Study of organ transplant patients [3]; Effects of ethanol exposure [31]; Dose effect study in child psychotherapy [34]; Multiple Sclerosis [19]; post-polio syndrom [53]; HIV associated dimenia [13];

 

Psychology, Psychometrics and Education

 

Reviews:; Wilkinson [25] sets guidelines

 

Methodology: Kesselman, Cribbie & Holland [23], Williams Jones & Tukey [24] - develop pairwise comparisons; Wainer [8]  adjusts graphical displays. Ip [56] developes the study local dependencies in item response problems.

 

Applications: National Assessment of  Educational Progress data [5,8,39,24]; Drug abuse [12]; Meta-analysis of psychoeducational programs for heart disease patients [26]; Mental health outcomes [42]; cross sectional study of bus drivers [55]

 

Genetics and Biology

 

Methodology: Basford & Tukey [6] develop graphical profiles aiding in plant breeding experiments; Weller et al [9,43] uses it in genetic mapping (QTL analysis), elicitating response by Zaykin, Young & Westfall [22]; Bovenhuis & Spelman [33] adapt the methods for selective genotyping; Drijalenko & Elston [11] finds the concept useful in mapping;

 

Applications: QTL analysis for milk production [20,43] and milk yield monitoring [29]; Breeding [6,50]; Defences in Daphnia [46]; Song imitation in Zebra Finches [16];

 

 

Signal Denoising and Image Processing

 

Methodology: Benjamini & Abramovich [4] develop adaptive thresholding of wavelet coefficients;

 

Aplications: High resolution defects detection [49]

 

Economics and Marketing

 

Methodology: Green & Babyak [7,20,40] develop multiple testing of constraints and individual parameters in structural equations models; Schaffer and Green [28] develop cluster based market segmentation

 

Meteorology

 

Applications: Long distances dependencies in pressure [32]

 

Statistical Theory

 

Reviews: Brown [48] reviews FDR development in an essay on statistical decision theory; Pigeot [32] reviews multiple testing.

 

Methodology: The use of FDR as variable selection strategy was developed by Abramovich et al,  and other interpretations can be found in George [47], George and Foster [51]. Shaffer found a connection to Duncan's semi Bayesian procedure.

 

List of References for Applications

 

 

[1] Schlaeppi M, Edwards K, Fuller RW, et al.

    Patient perception of the Diskus inhaler: A comparison with the Turbuhaler inhaler.

    BRIT J CLIN PRACT 50 (1): 14-19 JAN-FEB 1996

 

[2] Sharma RK, Edwards K, Hallett C, et al.

Perception among paediatric patients of the Diskus(R) inhaler, a novel multidose powder inhaler for use in the treatment of asthma - Comparison with the Turbuhaler(R) inhaler.

    CLIN DRUG INVEST 11 (3): 145-153 MAR 1996

 

[3] Thomason JM, Seymour RA, Ellis JS, et al.

Determinants of gingival overgrowth severity in organ transplant patients - An examination of the role of HLA  phenotype.

J CLIN PERIODONTOL 23 (7): 628-634 JUL 1996

 

[4] Abramovich F, Benjamini Y

    Adaptive thresholding of wavelet coefficients.

    COMPUT STAT DATA AN 22 (4): 351-361 AUG 10 1996

 

[5] Wainer H

    Depicting error.

    AM STAT 50 (2): 101-111 MAY 1996

 

[6] Basford KE, Tukey JW

    Graphical profiles as an aid to understanding plant breeding experiments.

    J STAT PLAN INFER 57 (1): 93-107 JAN 15 1997

 

[7] Green SB, Babyak MA

    Control of type I errors with multiple tests of constraints in structural equation modeling.

    MULTIVAR BEHAV RES 32 (1): 39-51 1997

 

[8] Wainer H

    Improving tabular displays, with NAEP tables as examples and inspirations.

    J EDUC BEHAV STAT 22 (1): 1-30 SPR 1997

 

[9] Weller JI, Song JZ, Ronin YI, et al.

    Designs and solutions to multiple trait comparisons.

    ANIM BIOTECHNOL 8 (1): 107-122 1997

 

[10] Brown BW, Russell K

    Methods correcting for multiple testing: Operating characteristics.

    STAT MED 16 (22): 2511-2528 NOV 30 1997

 

[11] Drigalenko EI, Elston RC

    False discoveries in genome scanning.

    GENET EPIDEMIOL 14 (6): 779-784 1997

 

[12] Hubbard RL, Craddock SG, Flynn PM, et al.

    Overview of 1-year follow-up outcomes in the Drug Abuse Treatment Outcome Study (DATOS).

    PSYCHOL ADDICT BEHAV 11 (4): 261-278 DEC 1997

 

[13] Robertson K, Fiscus S, Kapoor C, et al.

    CSF, plasma viral load and HIV associated dementia.

    J NEUROVIROL 4 (1): 90-94 FEB 1998

 

[14] Westfall PH, Young SS, Lin DKJ

    Forward selection error control in the analysis of supersaturated designs.

    STAT SINICA 8 (1): 101-117 JAN 1998

 

[15] Ottenbacher KJ

    Quantitative evaluation of multiplicity in epidemiology and public health research.

    AM J EPIDEMIOL 147 (7): 615-619 APR 1 1998

 

[16] Tchernichovski O, Nottebohm F

    Social inhibition of song imitation among sibling male zebra finches.

    P NATL ACAD SCI USA 95 (15): 8951-8956 JUL 21 1998

 

[17] Mallet L, Mazoyer B, Martinot JL

    Functional connectivity in depressive, obsessive-compulsive, and schizophrenic disorders: an

    explorative correlational analysis of regional cerebral metabolism.

    PSYCHIAT RES-NEUROIM 82 (2): 83-93 MAY 20 1998

 

[18] Spelman RJ, Bovenhuis H

    Moving from QTL experimental results to the utilization of QTL in breeding programmes.

    ANIM GENET 29 (2): 77-84 APR 1998

 

[19] Chen VJ, Bewley JR, Andis SL, et al.

Preclinical cellular pharmacology of LY231514 (MTA): a comparison with methotrexate, LY309887 and raltitrexed for their effects on intracellular folate and nucleoside triphosphate pools in CCRF-CEM cells.

    BRIT J CANCER 78: 27-34 Suppl. 3 1998

 

[20] Green SB, Thompson MS, Babyak MA

    A Monte Carlo investigation of methods for controlling type I errors with specification searches in

    structural equation modeling.

    MULTIVAR BEHAV RES 33 (3): 365-383 1998

 

[21] Weller JI, Song JZ, Heyen DW, et al.

    A new approach to the problem of multiple comparisons in the genetic dissection of complex traits.

    GENETICS 150 (4): 1699-1706 DEC 1998

 

[22] Harris LE, Luft FC, Rudy DW, et al.

    Effects of multidisciplinary case management in patients with chronic renal insufficiency.

    AM J MED 105 (6): 464-471 DEC 1998

 

[23] Keselman HJ, Cribbie R, Holland B

    The pairwise multiple comparison multiplicity problem: An alternative approach to familywise and

    comparisonwise type I error control.

    PSYCHOL METHODS 4 (1): 58-69 MAR 1999

 

[24] Williams VSL, Jones LV, Tukey JW

    Controlling error in multiple comparisons, with examples from state-to-state differences in

    educational achievement.

    J EDUC BEHAV STAT 24 (1): 42-69 SPR 1999

 

[25] Wilkinson L

    Statistical methods in psychology journals - Guidelines and explanations.

    AM PSYCHOL 54 (8): 594-604 AUG 1999

 

[26] Dusseldorp E, van Elderen T, Maes S, et al.

    A meta-analysis of psychoeducational programs for coronary heart disease patients.

    HEALTH PSYCHOL 18 (5): 506-519 SEP 1999

 

[27] Yekutieli D, Benjamini Y

Resampling-based false discovery rate controlling multiple test procedures for correlated test statistics.

    J STAT PLAN INFER 82 (1-2): 171-196 DEC 1 1999

 

[28] Schaffer CM, Green PE

    Cluster-based market segmentation: some further comparisons of alternative approaches.

    J MARKET RES SOC 40 (2): 155-163 APR 1998

 

[29] Lark RM, Nielsen BL, Mottram TT

    A time series model of daily milk yields and its possible use for detection of a disease (ketosis).

    ANIM SCI 69: 573-582 Part 3 DEC 1999

 

[30] Heyen DW, Weller JI, Ron M, et al.

    A genome scan for QTL influencing milk production and health traits in dairy cattle.

    PHYSIOL GENOMICS 1 (3): 165-175 NOV 11 1999

 

[31] Slawecki CJ, Somes C, Ehlers CL

Effects of prolonged ethanol exposure on neurophysiological measures during an associative  learning paradigm.

    DRUG ALCOHOL DEPEN 58 (1-2): 125-132 FEB 1 2000

 

[32] Pigeot I

    Basic concepts of multiple tests - A survey.

    STAT PAP 41 (1): 3-36 JAN 2000

 

[33] Bovenhuis H, Spelman RJ

    Selective genotyping to detect quantitative trait loci for multiple traits in outbred populations.

    J DAIRY SCI 83 (1): 173-180 JAN 2000

 

[34] Andrade AR, Lambert EW, Bickman L

    Dose effect in child psychotherapy: Outcomes associated with negligible treatment.

    J AM ACAD CHILD PSY 39 (2): 161-168 FEB 2000

 

[35] Witte JS, Elston RC, Cardon LR

    On the relative sample size required for multiple comparisons.

    STAT MED 19 (3): 369-372 FEB 15 2000

 

[36] Zaykin DV, Young SS, Westfall PH

    Using the false discovery rate approach in the genetic dissection of complex traits: A response to

    Weller et al.

    GENETICS 154 (4): 1917-1918 APR 2000

 

[37] Tierney WM, Harris LE, Gaskins DL, et al.

    Restricting Medicaid payments for transportation: Effects on inner-city patients' health care.

    AM J MED SCI 319 (5): 326-333 MAY 2000

 

[38] Suhy J, Rooney WD, Goodkin DE, et al.

H-1 MRSI comparison of white matter and lesions in primary progressive and relapsing-remitting MS.

MULT SCLER 6 (3): 148-155 JUN 2000

 

[39] Benjamini Y, Hochberg Y

    On the adaptive control of the false discovery fate in multiple testing with independent statistics.

    J EDUC BEHAV STAT 25 (1): 60-83 SPR 2000

 

[40] Cribbie RA

Evaluating the importance of individual parameters in structural equation modeling: the need for type I error control.

    PERS INDIV DIFFER 29 (3): 567-577 SEP 2000

 

[41] Curran-Everett D

    Multiple comparisons: philosophies and illustrations.

    AM J PHYSIOL-REG I 279 (1): R1-R8 JUL 2000

 

[42] Bickman L, Lambert EW, Andrade AR, et al.

The Fort Bragg continuum of care for children and adolescents: Mental health outcomes over 5 years.

    J CONSULT CLIN PSYCH 68 (4): 710-716 AUG 2000

 

[43] Ellis SP, Underwood MD, Arango V, et al.

    Mixed models and multiple comparisons in analysis of human neurochemical maps.

    PSYCHIAT RES-NEUROIM 99 (2): 111-119 AUG 28 2000

 

[44] Kanas N, Salnitskiy V, Grund EM, et al.

    Social and cultural issues during Shuttle/Mir space missions.

    ACTA ASTRONAUT 47 (2-9): 647-655 Sp. Iss. SI JUL-NOV 2000

 

[45] Kanas N, Salnitskiy V, Grund EM, et al.

    Interpersonal and cultural issues involving crews and ground personnel during Shuttle/Mir space

    Missions.

    AVIAT SPACE ENVIR MD 71 (9): A11-A16 Suppl. S SEP 2000

 

[46] Barry MJ

    Inducible defences in Daphnia: responses to two closely related predator species.

    OECOLOGIA 124 (3): 396-401 AUG 2000

 

[47] George EI

    The variable selection problem.

    J AM STAT ASSOC 95 (452): 1304-1308 DEC 2000

 

[48] Brown LD

    An essay on statistical decision theory.

    J AM STAT ASSOC 95 (452): 1277-1281 DEC 2000

 

[49] Recknagel RJ, Kowarschik R, Notni G

High-resolution defect detection and noise reduction using wavelet methods for surface measurement.

    J OPT A-PURE APPL OP 2 (6): 538-545 NOV 2000

 

[50] Luijten SH, Dierick A, Oostermeijer JGB, et al.

    Population size, genetic variation, and reproductive success in a rapidly declining, self-incompatible

    perennial (Arnica montana) in The Netherlands.

    CONSERV BIOL 14 (6): 1776-1787 DEC 2000

 

[51] George EI, Foster DP

    Calibration and empirical Bayes variable selection.

    BIOMETRIKA 87 (4): 731-747 DEC 2000

 

[52] Khatri P, Babyak M, Croughwell ND, et al.

    Temperature during coronary artery bypass surgery affects quality of life.

    ANN THORAC SURG 71 (1): 110-116 JAN 2001

 

[53] Trojan DA, Collet JP, Pollak MN, et al.

Serum insulin-like growth factor-I (IGF-I) does not correlate positively with isometric strength, fatigue, and quality of life in post-polio syndrome.

    J NEUROL SCI 182 (2): 107-115 JAN 1 2001

 

[54] Stine RA, Heyse JF

    Non-parametric estimates of overlap.

    STAT MED 20 (2): 215-236 JAN 30 2001

 

[55] Vedantham K, Brunet A, Boyer R, et al.

    Posttraumatic stress disorder, trauma exposure, and the current health of Canadian bus drivers.

    CAN J PSYCHIAT 46 (2): 149-155 MAR 2001

 

[56] Ip EH

    Testing for local dependency in dichotomous and polytomous item response models.

    PSYCHOMETRIKA 66 (1): 109-132 MAR 2001